How to schedule and optimize follow up messages in Tweetdm for b2b sales

Reaching out to prospects on Twitter is one thing. Actually getting replies, starting conversations, and booking meetings? That’s the tricky part. If you’re in B2B sales, you already know that follow-up makes the difference—most deals don’t close after a single DM.

This guide is for people who want to use Tweetdm to automate and improve those crucial follow-ups, without sounding like a robot or wasting time on stuff that doesn’t move the needle.

Let’s get right into it.

1. Why Follow-Ups Matter (and What Most People Get Wrong)

First, reality check: Most of your prospects won’t respond to your first message. Not because they hate you, but because they’re busy, distracted, or just missed it.

Here’s what usually doesn’t work: - Sending a generic “just following up” DM three days later. - Spamming the same message over and over. - Using a sequence that’s so obviously automated that it kills any chance of a real reply.

If you want responses, you have to: - Respect people’s time. - Make each message count. - Follow up enough—but not so much you get blocked.

Automating with Tweetdm helps, but only if you set it up thoughtfully.

2. Setting Up Your Tweetdm Campaign for B2B Sales

Before you start scheduling follow-ups, get your Tweetdm basics right:

  1. Define your audience carefully.
    Don’t just cast a wide net. Use filters or lists to target the right roles, industries, or companies. (If you’re still messaging random accounts, you’re wasting everyone’s time.)

  2. Draft your initial outreach message.

  3. Be direct about why you’re reaching out.
  4. Avoid “hope you’re well” fluff.
  5. Mention something specific about them, if possible.

Example:

“Hi [Name], saw your post about [topic]. Curious if you’re tackling [problem] at [Company]? I’ve worked with similar teams on this—happy to share what’s worked.”

  1. Plan your follow-up sequence.
    Don’t wing it. Decide upfront:
  2. How many follow-ups will you send?
  3. How many days between each?
  4. What will each message say?

Pro tip:
Two to four follow-ups is usually plenty. More than that and you’re probably annoying people.

3. How To Schedule Follow-Up Messages in Tweetdm

Tweetdm makes it easy to automate DMs, but you have to set it up right. Here’s how:

Step 1: Create Your Sequence

  • In your Tweetdm dashboard, look for the “Sequences” or “Campaigns” section.
  • Add your first message—the one you’d send manually.
  • Click “Add Step” or similar to create your first follow-up.

Step 2: Space Out Your Messages

  • Set at least 2–3 days between each message.
    (Daily follow-ups just annoy people—space gives them a breather.)
  • If you’re selling to executives or founders, wait 4–5 days—they’re even busier.

Step 3: Personalize, Even If You Automate

  • Use merge tags for first name, company, or recent tweet.
  • Don’t overdo it with fake personalization—if you can’t add something real, keep it short and honest.

Example Follow-Up Sequence:

  1. Initial DM:
    Direct, with a specific reason for reaching out.

  2. Follow-Up #1 (3 days later):

    “Just checking if you saw my previous message, [Name]. No rush—let me know if this isn’t a fit.”

  3. Follow-Up #2 (4 days later):

    “Quick nudge—totally understand if now’s not the right time. Happy to share examples if you’re curious.”

  4. Optional Final Nudge (5+ days later):

    “No worries if you’re not interested. If things change, my DMs are open.”

What to avoid:
- Guilt trips (“I guess you’re ignoring me…”) - Overly persistent messaging (“I know you’re busy, but…” repeated endlessly) - Fake scarcity (“This is your LAST CHANCE!”)

Step 4: Set Conditions and Stop Rules

  • Use Tweetdm’s “stop on reply” feature so prospects who respond don’t get more automated messages.
  • You can also set rules to stop messaging if someone unfollows, blocks, or is inactive.

4. Writing Follow-Ups That Actually Get Replies

Automation is only as good as your writing. Here’s what matters:

  • Keep it short.
    No one reads a wall of text in Twitter DMs.
  • Remind, don’t repeat.
    Reference your earlier message, but add a new angle or offer value.
  • Make it easy to say no (or yes).
    Sometimes, just giving people a polite out (“If this isn’t for you, no worries at all”) increases reply rates.

What works: - Asking a simple question. - Offering a resource (case study, article, example). - Being direct about next steps: “Does it make sense to chat for 10 minutes this week?”

What doesn’t: - Overcomplicated CTAs (“Let me know if you want to schedule a call, or if you’d like more info, or if…”) - Sounding desperate (“I really need your feedback on this!”)

5. Optimizing Your Follow-Up Sequences (Beyond Just Scheduling)

Scheduling is just the start. You’ll need to tweak and improve as you go. Here’s how:

Track What’s Working (and What Isn’t)

  • Check Tweetdm’s analytics for open rates, replies, and stops.
  • If nobody responds after the first message, your opener needs work.
  • If people reply but never book a call, your follow-ups may be too generic.

Test New Approaches—But Keep It Simple

  • Try swapping in a question instead of a statement for follow-up #2.
  • Alternate between “soft” touchpoints (offering value, sharing an article) and direct asks.
  • Don’t run 10 variations at once—you’ll just confuse yourself.

Don’t Get Cute With Automation

  • Resist the urge to over-personalize with fake details (“I see you love skiing!” when you actually scraped it from their bio).
  • Avoid scheduling messages at weird hours. Stick to business hours in your prospect’s time zone.

Know When to Stop

  • If someone hasn’t responded after 3–4 messages, move on. Pushing harder doesn’t magically create interest.
  • Remove unresponsive contacts from future campaigns. Focus on people who actually engage.

6. Things to Ignore (That Won’t Help Your Results)

  • Overly clever copywriting.
    You’re not writing ad jingles; you’re starting a conversation.
  • Fancy graphics or links in DMs.
    Twitter DMs are for quick, plain-text messages. Links can even get you flagged as spam.
  • “Growth hacks” that promise 10x replies.
    Most are recycled tricks that’ll get you blocked or ignored.

Focus on clarity and respect. That’s what gets replies.

7. Real-World Tips From People Who’ve Done This

  • Use Tweetdm to free up your time, not replace your judgment.
    Review your sequences every couple of weeks. If you wouldn’t reply to your own messages, fix them.
  • Keep track of replies and update your CRM.
    Don’t let warm leads fall through the cracks just because you automated the outreach.
  • Batch your campaign reviews.
    Set a recurring reminder to check your Tweetdm stats and adjust sequences—don’t just “set and forget.”

Keep It Simple (and Don’t Overthink It)

Automated follow-ups save you time, but they’re not magic. The basics still matter: clear messaging, real value, and respecting people’s attention. Start simple, pay attention to what actually gets replies, and tweak as you go.

You don’t need to be perfect—just a little better than everyone else blasting out mindless DMs. That’s how you get conversations started, and that’s what leads to real B2B sales.